Lisiecki was born in Calgary, Alberta to Polish parents. He began studying piano at the age of five. Lisiecki had his orchestral debut at the age of nine, and has since performed with orchestras in Canada and internationally, including the New York Philharmonic, Orchestre de Paris, BBC Symphony Orchestra, Rotterdam Philharmonic Orchestra, National Arts Centre Orchestra, Montreal Symphony Orchestra, to name a few. Lisiecki has performed with conductors Claudio Abbado, David Zinman, Paavo Järvi, Antonio Pappano and Yannick Nézet-Séguin. On January 1, 2010 Lisiecki opened the Chopin 200th Birthday celebrations from the composer’s birthplace, Żelazowa Wola. The same month, he performed Chopin Concerto No. 1 in E minor at the MIDEM Classical Awards Gala in Cannes, France. Lisiecki performed for Her Majesty Queen Elizabeth II and a hundred thousand people on Parliament Hill in Ottawa, Ontario, Canada, as part of the Canada Day 2011 celebrations.
Lisiecki has played at the Royal Albert Hall, Avery Fisher Hall, Carnegie Hall, Salle Pleyel, Tonhalle Zürich, Konzerthaus Vienna, and Suntory Hall, and has substituted for pianists such as Martha Argerich, Radu Lupu, and Nelson Freire. Lisiecki has shared the stage with Yo-Yo Ma, Pinchas Zukerman, James Ehnes, Emanuel Ax, and Truls Mørk performing at various concert venues in Armenia, Belgium, Brazil, Canada, China, Czech Republic, France, Germany, Guatemala, Greece, Italy, Japan, Lebanon, Luxembourg, The Netherlands, Norway, Poland, South Korea, Spain, Sweden. Switzerland, UK, and the US.